Citicoline is a medicine available in a number of countries worldwide. A list of US medications equivalent to Citicoline is available on the website. Choline C 11 Injection, for intravenous use. Initial U.S. Approval: INDICATIONS AND USAGE Choline C The Federal Food, Drug, and Cosmetic Act requires that manufacturers and distributors who wish to market dietary supplements that contain.

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It should not be construed to indicate citicoilne the use of any medication in any country is safe, appropriate or effective for you.

London UK ; e-version. This means it is still under development and may contain inaccuracies. The effect of citicoline on visual function has been studied in patients with glaucoma. Reviews in Neurological Diseases. To view content sources and attributions, please refer to our editorial policy. Nicotinic acetylcholine receptor modulators. British Journal of Pharmacology. Citicoline In the US, Citicoline is a member of the drug class oral nutritional supplements.

Home International Citicoline Print Share. By using this site, you agree to the Terms of Use and Privacy Policy. Subscribe to free Citlcoline. Journal of Neuroscience Research. From Wikipedia, the free encyclopedia. Close regulation of its biosynthesis, degradation, and distribution is essential to proper cell citickline.

The Complete Drug Reference [ed. Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea. Citicoline is available as a supplement online and in stores.

Studies suggest that CDP-choline supplements increase dopamine receptor densities. It is sold in over 70 countries under a variety of brand names: Methods and Findings in Experimental and Clinical Pharmacology.


Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A review of published clinical trials of citicoline noted that while some studies have demonstrated positive effects of the compound on cognition, other studies have failed to confirm these results and additional clinical trials would be needed to confirm any potential benefits of citicoline.

By clicking Subscribe, I agree to the Drugs. The Journal of Biological Chemistry. Citicoline INNalso known as cytidine diphosphate-choline CDP-Choline or cytidine 5′-diphosphocholine is an intermediate in the generation of phosphatidylcholine from cholinea common biochemical process in cell membranes.

Citicoline wins EU novel foods approval – in medical foods and food supplements

Subscribe to receive email notifications whenever new articles are published. The brain preferentially uses choline to synthesize acetylcholine. Citicoline lowers increased glutamate concentrations and raises decreased ATP concentrations induced by ischemia.

Muscarinic acetylcholine receptor modulators.

Available for Android and iOS devices. A meta-analysis of randomized controlled trials”. Cytidine 5′- trihydrogen diphosphatemono[2- trimetylammonio etyl] ester, hydroxide, inner salt.

This page was last edited on 14 Septemberat Consult with your healthcare professional before taking any medication. Despite some suggestions that citicoline may reduce the rates of death and disability following an ischemic stroke[10] [11] the largest citicoline citivoline trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling patients, found no benefit of administering citicoline on survival or recovery from stroke.

Int J Mol Sci.

Citicoline enhances cellular communication by increasing the availability of neurotransmitters, including acetylcholinenorepinephrineand dopamine. Retinol Vitamin A B vitamins: Views Read Edit View history. These phospholipids include sphingomyelin and phosphatidylcholine.


Phosphatidylcholine is synthesized in vivo by two pathways. It is not intended as a substitute for the expertise and judgement of citjcoline physician, pharmacist or other healthcare professional.

The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelinpreservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolaminepartial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

We comply with the HONcode standard for trustworthy health information – verify here. This material is provided fdx educational purposes only and is not intended for medical advice, diagnosis or treatment.

Citicoline wins EU novel foods approval – in medical foods and food supplements

Further information on drug naming conventions: Phosphatidylcholine is a major phospholipid in eukaryotic cell membranes. In the US, Citicoline is a member of the drug class oral nutritional supplements. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. When the availability of choline is low or the need for acetylcholine increases, phospholipids containing choline can be catabolized from neuronal membranes.

Citicoline also increases glutamate uptake by increasing expression of EAAT2a glutamate transporterin vitro in rat astrocytes.