Autoimmune hepatitis (AIH) is also known historically as chronic aggressive hepatitis, plasma cell hepatitis, lupoid hepatitis and chronic active hepatitis. Am J Med Sci. Apr;(4) doi: / Epub Nov 4. Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis). Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. This immune response causes inflammation of the liver, also called.

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Some may also have their kidney function affected by this medication so that must be monitored lupoif bloodwork. Many people have only laboratory abnormalities as their initial presentation, as unexplained increase in transaminases and are diagnosed during an evaluation for other reasons.

Autoimmune hepatitis

Read more Autoimmune Hepatitis Stories. Type 1 AIH, also referred to as the classic type, is typically diagnosed in adulthood, whereas type 2 is diagnosed during childhood. Viruses cause many types of hepatitis. Related Joint pain Nausea and vomiting Fatigue. Initial bloodwork will include checking for signs of liver inflammation, liver function, autoimmune markers, and other blood tests to rule out other causes of liver disease. You must be a registered member of Cancer Therapy Advisor to post a comment.

Request an Appointment at Mayo Clinic. Cyclosporine, sirolimus Rapamuneand tacrolimus Prograf are other alternative treatments to azathioprine and mycophenolate mofetil. Increased bilirubin may indicate severe inflammation associated with the disease, but may also indicate decreased liver function.


Men and women can develop Autoimmune Hepatitis but it is 3 to 4 times more common in women. Mayo Clinic does not endorse companies or products. Management with Co-Morbidities A.

There are no imaging studies that would help establish the diagnosis. By registering you consent to the collection and use of your information to provide the products and services you have requested from us and as described in our privacy policy and terms and conditions. They may lupid slowly develop over time.

Gastrointestinal or Nutrition Issues J. Current medical diagnosis and treatment page. The periportal lesion, referred to as piecemeal necrosis or interface hepatitis, essentially spares the biliary tree but may involve more of the lobule.

Autoimmune hepatitis – Symptoms and causes – Mayo Clinic

It can reveal the type and severity of your liver damage and inflammation. It may be possible to stop treatment in a few people with AIH, however this is not without risk as a relapse becoming ill again can occur and you may need further treatment. Merck Manual Professional Version. Infections such as viral hepatitis hepatitis A, B, C, and Dherpes simplex virus, and cytomegalovirus have also been linked to disease onset.

The nomenclature and diagnostic criteria for these variant forms of AIH have not been standardized yet. Many autoimmune diseases will cause an elevated ANA and IgG so if those are elevated it does not mean you have AIH, just that you may be more likely to have an autoimmune condition.


Not applicable as treatment can be pursued as an outpatient. Despite pupoid good initial response to immunosuppression, recent studies suggest that the life expectancy of patients with autoimmune hepatitis is lower than that of the general population.

Hepatology clinic follow-up should be arranged within weeks after initiation hepatitks treatment. Your doctor will prescribe a dose tell you how much of the medication for you to take; this will depend on your weight and condition.

People with liver disease are more vulnerable to infection and to poor health overall, so smoking or exposure to hepatltis smoking is not advisable.

Lupus Hepatitis and Autoimmune Hepatitis (Lupoid Hepatitis).

Other autoimmune conditions can cause symptoms of liver disease and are also associated with the development of AIH. D ICD – AIH was the first chronic liver disease to have a dedicated treatment. Prednisone is a common first treatment. All studies receiving U. Gastrointestinal or Nutrition Issues Azathioprine heepatitis result in nausea, vomiting and diarrhea that may exacerbate symptoms from pre-existing gastrointestinal disease.

Investigational Therapies Methotrexate, rapamycin, rituximab, and infliximab have been used in a small subset of patients with AIH who did not respond well to the drugs discussed above. It is used to treat Hepatitks Hepatitis and other chronic inflammatory and autoimmune conditions.